Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro–in vivo correlations
نویسندگان
چکیده
منابع مشابه
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Several small molecule tyrosine kinase inhibitors (TKIs) inhibit c-Kit, an effect associated with myelosuppression and hair depigmentation. We studied a panel of approved and investigational TKIs for inhibitory activity against FLT3 and c-Kit, and on hematopoietic progenitor cells. Potent cKit inhibitors such as dasatinib, pazopanib, and quizartinib demonstrated the greatest disruption of hemat...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2014
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2013.811